Multi-systemic symptoms are a red flag for hATTR, with autonomic dysfunction present in almost all mutations.2-3
With mixed-phenotype hATTR expected in up to 80% of patients (depending on mutation), multi-disciplinary consultation is crucial.4,5
hATTR:hereditary transthyretin amyloidosis.
References: 1. Nativi-Nicolau JN, Karam C, Khella S, Maurer MS. Heart Fail Rev. 2022;27(3):785-793. 2. Alcantara M, et al. Can J Neurol Sci. 2022;49:7-18. 3. Gonzalez-Duarte A, Valdes-Ferrer SI, Cantu-Brito C. Clin Autonom Res. 2019;29(Suppl 1):S1-S9. 4. Fine N, et al. CJC Open. 2025;7(5):614-627. 5. Kittleson MM, et al. J Am Coll Cardiol. 2023;81(11):1076-1126.
References: 1. Nativi-Nicolau JN, Karam C, Khella S, Maurer MS. Heart Fail Rev. 2022;27(3):785-793. 2. Alcantara M, et al. Can J Neurol Sci. 2022;49:7-18. 3. Gonzalez-Duarte A, Valdes-Ferrer SI, Cantu-Brito C. Clin Autonom Res. 2019;29(Suppl 1):S1-S9. 4. Fine N, et al. CJC Open. 2025;7(5):614-627. 5. Kittleson MM, et al. J Am Coll Cardiol. 2023;81(11):1076-1126.
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